Friday, April 01, 2005

Friday Thalassemic Zebra Fish Blogging

Thalassemia is a blood disease and is one of several linked to malarial resistance (others being the more widely known sickle cell anemia and G6PD. In humans it is an autosomal dominant that acts on the synthesis of either alpha or beta chains in hemoglobin. Homozygotes rarely survive childhood without medical care. Heterozygotes have a milder form and are usually free of symptoms. Thalessemia has mainly been studied in humans. Recently, however, it has been found in Zebra fish . From the article:

"In fact, six different zebrafish strains were found to have some equivalent of human thalassemia, "but only one of these mutants is linked to globin [the component of hemoglobin that accounts for the color of red blood cells]," Zon says. "So there must be five other genes that regulate globin expression, yet nobody knew about them."
Posted by Hello
Picture from Pharyngula (where else?)
Along with thalessemia researchers found several other, human blood diseases. Zebra fish are widely used in developmental biology for several reasons. For example, they have short generation times and produce a large number of offspring.Posted by Hello
Also from Pharyngula
The interesting thing about this is that human diseases can be studied in zebra fish and the genetics can be more easily worked out. Of course this research has evolutionary implications, in that we can also study changes in genes between zebrafish and humans - but that's a different post.
Posted by Hello
Yup, this one too

Interesting Link:The Zebrafish Project Developmental neurobiology for high-school scientists